As timely posted in our Web and Facebook page,
several members of CliNK actively participated in the 3rd European
Congress of Immunology (ECI), celebrated in Glasgow from the 5th to
9th September.
Miguel López-Botet belonged to the scientific organizing committee and have contributed to the high quality of the scientific session organization.
The City of Glasgow Pipers at
the Civic Reception
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The first day, the ECI Bright
Sparks in Immunology session was followed by the keynote lecture by
Nobel Prize Winner Sir Martin Evans at the Opening Ceremony followed
by a welcome to Glasgow and Scotland from the Lord Provost. A company
of Pipers from the city of Glasgow accompanied the following Civic
Reception.
The second day, the great number of scientific
sessions began, and it is impossible to summarize all of them in a
small space, so we will signal some of those with more interest to
the CliNK thematic.
Of those, the first was the Symposium on
“Recognition of dysregulated self”, in which Eric Vivier spoke
about the plasticity of NK cells and their role in immune effector
and regulatory functions and Alessandro Moretta about data on NK cell
maturation driven by human cytomegalovirus (CMV) after hematopoietic
stem cell transplantation. In the symposium devoted to extreme
immunological phenotypes and immune deficiencies, Gillian Griffiths
presented her recent and past work on the control of CTL
degranulation, based in part in immune pathologies characterized by
defective degranulation. In the afternoon, an interesting workshop
was devoted to Lymphocyte signaling mechanisms, and another one to
Tolerance and apoptosis, with communications offering recent advances
in the field.
Dr. López-Botet during his
talk at the plenary symposium
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Next day, Dr. López-Botet gave
a talk in the plenary Symposium devoted to Immunity to infection. The
talk was entitled “CMV infection reshapes the human NK cell
compartment promoting a persistent expansion of CD94/NKG2C+
cells”.
This same day, Alberto Anel was the chairman,
together with Daniel Pinschewer, of the Workshop devoted to cytolytic
T cells, in which several aspects of CTL biology were analyzed, from
the proteomic characterization of different types of cytotoxic
granules (Ottmar Janssen) to the anti-tumor mechanisms used by CTL to
eliminate tumors upon anti-CD137 mAb treatment (Ignacio Melero &
Julián Pardo). Another workshop was devoted to tumor immunology,
with recent advances, promise of future immunotherapy treatments.
The last day of the Congress
offered a Symposium on Cancer, with talks by Hans Stauss on adoptive
T cell therapy of cancer, of which those directed to the Wilms tumor
1 antigen goes to the clinic in 2013, and by Alberto Mantovani on the
dark side of inflammation and macrophages as tumor promoters. We
finished with the Worskhop more interesting to CliNK, that devoted to
NK cells, with Peter Höglund and Angela Santoni as chairmen. All the
talks were on relevant recent advances, with Mariella della Chiesa
from the Moretta lab talking on the development of human NK cells
after intrabone umbilical cord blood transplantation and Chiara
Romagnani on the dynamics of differentiating and adoptively
transferred NK cells in patients undergoing hematopoietic stem cell
transplantation.
Aura Muntasell at her poster |
Elena Catalán at her poste
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Elena Catalán, from the Anel lab, also presented the poster entitled “MHC-I modulation due to metabolic changes regulates tumor sensitivity to NK cells”, related with the relationship between glucidic metabolism in tumors and their sensitivity to NK cell-mediated cytotoxicity, work developed inside the CliNK consortium in collaboration with the group of Martín Villalba.
Julián Pardo also assisted to the congress
sessions, presenting a communication related with the antitumoral
potential of CTL entitled “In vivo elimination of drug-resistant
tumor cells by cytotoxic T cells through a perforin/granzyme
B-dependent mechanism”
The best presentation was by Gillian Griffiths
ResponderEliminar